Corio PSP™
(Coriolus Versicolor)
The Anti-Tumor and Immune-Modulatory Mushroom
Corio PSP™ is so-named because its main constituent—the
Coriolus versicolor mushroom—contains 22 percent
polysaccharide-peptides (PSP).
Coriolus versicolor is the most widely researched
immune-enhancing mushroom. This mushroom is ranked Number 1 by John
Boik in his highly acclaimed book entitled
Natural Compounds In Cancer Therapy.
Physiological Effects of Coriolus
- Promotes the proliferation of T cells and pre-T cells.
- Increases thymus weight.
- Increases the biological effects of radiation.
- Possesses direct cytotoxic effects to tumor cells and inhibits tumor growth.
- Increases the production of IL-2, IgG, C3, and interferon.
- Raises the activities of NK cells and macrophages.
- Maintains and raises white blood cell count.
- Lessens the side effects of chemotherapy and radiotherapy.
- Reduces pain in terminal patients.
- Prevents liver injuries induced by CCl4 (carbon-tetrachloride-based drugs).
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Main Ingredients
Corio PSP is composed of 22 percent polysaccharides. These polysaccharides
have a main chain of an alpha and beta (1-4) glucan, and tightly bound 15-38% polypeptides. The polysaccharides are composed of six types of monosaccharides: galactose, glucose, mannose, xylose, arabinose, and rhamnose. The peptide portion consists mainly
of aspartic acid and glutamic acid.
Dosage
1 to 3 grams per day for maintenance; 3 to 6 grams per day for optimal effects.
Toxicity
LD50 > 20g/kg. Ames test, tests for abnormalities in chromosomes, nucleotides, and reproduction are all negative. The use of 50 times human clinical dosage on monkeys consecutively for 6 months produced no toxic effects.
References
Yang QY, Yong SC, Yang XT. The physio-chemical characteristics of the polysaccharide-peptide (PSP) of Coriolus versicolor (Yun Zhi). In: Report on the polysaccharide-peptide (PSP) of Coriolus versicolor, 1987: pp1-6. Landford. China.
Liu WK, Ng TB, Sze SF, Tsui KW. Activation of
peritoneal macrophages by polysaccharopeptide from the mushroom Coriolus versicolor. Immunopharmacology 1993; 26: 139-146.
Dong Y, Kwan CY, ChenZN, Yang MMP. Antitumor effects of a refined polysaccharide peptide fraction isolated from Coriolus versicolor: in vitro and in vivo studies. Research communication in Molecular Pathology and Pharmacology 1996, 92(2): 140-148.
Yang QY, Yan P. Isolation of the polysaccharide components of PSP. J. Shanghai Teach. Univ. (Natural Sciences Ed.) 1986; 4: 36.
Liu TF, Xue WC. Clinical implication of PSP in oncology. In: Recent Advances in Cancer, published by Cancer Research Group, CUHK, 1989: 57-62.
Li SM, Xu LZ. A study of anti-cancer effects of PSP and PSK on human tumor cell lines in vitro. Acta Acad. Med., Shanghai, 1987, 14: 23-24.
Zhou JX, Li XY, Shen XL. The anti-tumor and immunomodulating activity of PSP in mice. J. Shanghai Teach. Univ. (Natural Sciences Ed.) 1988, 3:72.
Li SY, Wang JF. Immuno-modulating actions of PSP. In: Recent Advances in Cancer, published by Cancer Research Group, CUHK, 1989: 45-56.
Li XY, Wang JF, Zhu PP, Ge JB, Yang SX. Immune enhancement of polysaccharides peptides isolated from Coriolus versicolor. Acta Pharm. Sinica 1990, 11: 542-45.
Yang MMP, Chen ZN, Kwok JSL. The anti-tumor effect of a small polypeptide from Coriolus versicolor. American J. Chinese Med. 1992, 20: 221-232.
Shiu WCT, Leung TWT, Tao M. A clinical study of PSP on peripheral blood counts during chemotherapy. Phytotherapy Res. 1992, 6: 217.
Xue WC, Liu TF. Clinical experience in the use of PSP. Cancer Hospital, Shanghai Medical University.
Sun ZY, et al. The preliminary appraisal of polysaccharide peptide (PSP) in malignant and non-malignant diseases. Shanghai Medical University.
Zhou JX, Shen XL, Shen ZM, Li XY. Antitumor effect of polysaccharide peptide of Coriolus versicolor (PSP) and its mechanism. Department of Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai, China.
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