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CordImmune™
(Cordyceps with Cordycepin)
The Ultimate Anti-aging Mushroom
The Cordyceps mushroom, Cordyceps sinensis, has the
reputation of being one of the best anti-aging materials in Traditional Chinese Medicine.
Modern research has shown its anti-aging effects on virtually all systems of the human body.
Cordyceps has been used for centuries to protect and enhance
sexual, immune, liver,
kidney, and heart functions. It is
also a great adaptogen for anti-stress support.
CordImmune™ is a revolutionary new product that has all the benefits of the traditional Cordyceps,
plus the presence of Cordycepin gives it extra immune support.
CordImmune™ is the only product on the market that contains pure extracts from
the Super CS-4 strain of Cordyceps sinensis, a new hybrid strain that is capable of producing high yields of
both Adenosine and Cordycepin. Traditionally, Cordycepin has only been found in extracts from Cordyceps millitaris and not in Cordyceps sinensis.
Potential Applications of Cordyceps
- As an anti-aging supplement which improves almost all organ functions and the quality of life.
- Protection of liver and kidney from toxic drugs.
- Sports performance and endurance enhancement.
What is Cordycepin?
Cordycepin is also known as 3’-deoxyadenosine, a nucleoside
analog and a transcription chain terminator. When Cordycepin is introduced
to cells undergoing DNA replication, it produces a defective DNA that triggers
cells to undergo apoptosis (programmed cell death).
Currently, the National Cancer Institute in collaboration
with a pharmaceutical company has initiated a Phase I clinical study of
Cordycepin as a potential treatment agent.
However, we believe that the whole Cordyceps mushroom would
be more potent than a single extract such as Cordycepin alone. We believe that the synergistic effects of Cordyceps polysaccharides, adenosine, cordycepic acid, and cordycepin would be much greater than those achieved by the use of
Cordycepin alone.
Research Results
Cordyceps
Following are results of anti-aging studies of Cordyceps on
various body systems.
- Cellular ATP: Cordyceps improves sexual function (17) and is traditionally used for fatigue
(18).
- Hepatic system (the liver): Cordyceps activates Kupffer cell function, increases SOD and glutathione peroxidase in
the liver, raises plasma albumin, and inhibits inflammation and liver fibrosis (1-3).
- Cardiovascular system: Cordyceps inhibits thrombus formation, hypotensive, mildly inhibits platelet aggregation, vasodilation, reduces heart rate, reduces arrhythmia induced by aconitine,
and is hypolipidemic (13-16).
- Immune system: Cordyceps modulates cellular immune function, inhibits humoral immune hyperfunction, prevent inhibition of NK cells by cyclophosphamide, protects T helper cells from immunosuppression effects of prednisolone acetate and cyclophosphamide, prolongs allograft survival time,
and increases spleen weight (4-6).
- Endocrine system: Cordyceps increases corticosteroid production (differently than ACTH)
and stimulates bone marrow hematogenesis function (7-8).
- Malignant cells: Cordyceps inhibits Ehrlich ascites carcinoma, Meth A fibrosarcoma, K562, Jurkat, WM-1342, HL-60, and RPMI-8226 cell lines,
and promotes differentiation (9-12).
Cordycepin
Following are results of fundamental studies of Cordycepin.
- Anti-viral: Inhibits the replication of western equine encephalitis virus (19), herpes simplex virus (20,
29), and influenza virus (26).
- Anti-bacterial: Inhibits growth of Clostridium spp. without adverse effects on the growth of Bifidobacterium spp.(21).
- Anti-fungal: Inhibits Candida albicans and Candida krusei (24).
- Immune-regulatory: Up-regulates Interleukin-10 production and inhibits
Interleukin-2 production (22).
- Apoptotic: Induces apoptosis in ADA-inhibited TdT-positive leukemia cells (23,
25).
- Radiation damage enhancement: Inhibits the repair of X-ray induced DNA damage (27,
28, 30, 31.
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Main Ingredients of Cordyceps
The Cordyceps mushroom is comprised of polysaccharides, adenosine, adenine, uracil, guanine, thymin deoxyriboside, uracil deoxyriboside, 18 different amino acids (including 8 essential ones), polypeptides, mannitol, protein, organic acids, different micronutrients (P, Se, K, Ca, Mg, Mn, Fe, Na, Cu, Zn, Al, Si, Cr, V, Ni, Sr, Ti, and Mo), vitamins (B1, B2, B12, E,
and K), ergosterol, superoxide dismutase (SOD), etc.
Dosage
1 to 3 grams per day for maintenance; 3 to 6 grams per day for optimal effects.
Toxicity
A 3-month, placebo-controlled, sub-acute toxicity study in both sexes of rats found the CS-4 strain caused no toxicity or death at a dosage of 3 g/kg
orally. A 30-day, placebo-controlled toxicity study in mice found no signs of toxicity and no deaths from CS-4. In both studies, organ weights and peripheral blood cells were not significantly different from those of the controls.
Cordyceps References
-
Nakamura K, Yamaguchi Y, Kagota S, et al. 1999. Activation of in vivo Kupffer cell function by oral administration of
Cordyceps sinensis in rats. Jpn. J. Pharmacol. 79: 505-508
-
Liu P, Zhu J, Huang Y, Liu C. 1996. Influence of
Cordyceps sinensis (Berk.) Sacc. and rat serum containing same medicine on IL-1, IFN, and TNF produced by rat Kupffer. China J. Chin. Materia Medica. 21: 367-69.
-
Zhu JL, Liu C. 1992. Modulating effects of extractum semen
Persicae and cultivated Cordyceps hyphae on immuno-dysfunction of in-patients with post-hepatitis cirrhosis. Chung-Kuo Chung His I Chieh Ho Tsa Chih. 12:207-09.
-
Chen GZ, Chen GL, Sun T, Hsieh GC, Henshall JM. 1991. Effects of
Cordyceps sinensis on murine T lymphocyte subsets. Chin. Med. J. 104:4-8.
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Zhu XY, Yu HY. 1990. Immunosuppressive effect of cultured
Cordyceps sinensis on cellular immune response. Chin. J. Modern Developments Traditional Med. 10: 485-87.
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Zhang Z, Xia SS. 1990. Cordyceps sinensis-I as an immunosuppressant in heterotopic allograft model in rats. J. Tongji Med. Univ. 10:100-103.
-
Chen DM. 1987. Platelet hemopoiesis and ultrastructure observations in mice treated with natural
Cordyceps sinensis and its cultured mycelia. Bull. Chin. Materia Medica. 12: 47-49.
-
Li Y, Chen GZ, Jiang DZ. 1993. Effect of Cordyceps sinensis on erythropoiesis in mouse bone marrow. Chin. Med. J. 106: 313-16.
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Yoshida J, Takamura S, Yamaguchi N, et al. 1989. Antitumor activity of an extract of
Cordyceps sinensis (Berk.) Sacc. against murine tumor cell lines. Jpn. J. Exp. Med. 15: 157-161.
-
Kuo YC, Lin CY, Tsai WJ, et al. 1994. Growth inhibitors against tumor cells in
Cordyceps sinensis other than cordycepin and polysaccharides. Cancer Invest. 12:611-615.
-
Nakamura K, Yamaguchi Y, et al. 1999. Inhibitory effect of
Cordyceps sinensis on spontaneous liver metastasis of Lewis lung carcinoma and B16 melanoma cells in syngeneic mice. Jpn. J. Pharmacol 79: 335-341.
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Zhao DH, Lin LZ. 1995. Effect of Jinshuibao capsules on the immunological function of 36 patients with advanced cancer. Chung-Kuo Chung His I Chieh Ho Tsa Chih. 15:476-78.
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Feng MG, Zhao QG, Feng GH. 1987. Vasodilating effect of cultured
Cordyceps sinensis (Berk.) Sacc. mycelia in anesthetized dogs. Bull. Chin. Materia Medica. 12: 41-45.
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Ikumoto T, Sasaki S, Namba H, et al. 1991. Physiologically active compounds in the extracts from tochukaso and cultured mycelia of Cordyceps and Isaria. J. Pharm. Soc. Jpn. 111: 504-509.
-
Zhao Y. 1991. Inhibitory effects of alcoholic extract of
Cordyceps sinensis on abdominal aortic thrombus formation in rabbits. Chin. Med. J. 71: 612-615.
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Mei QB, Tao JY, et al. 1989. Anti-arrhythmic effects of
Cordyceps sinensis (Berk.) Sacc. China J. Chin. Materia Medica. 14: 616-618
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Yang WZ, Deng Xa, Hu W. 1985. Treatment of sexual hypofunction with
Cordyceps sinensis. Jiangxi Zhongyiyao. 5: 46-47.
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Manabe N, Sugimoto M, et al. 1996. Effects of the mycelial extract of cultured
Cordyceps sinensis on in vivo hepatic energy metabolism in the mouse. Jpn. J. Pharmacol. 70:85-88.
Cordycepin References
-
Hashimoto K, Simizu B. 1976. Effects of Cordycepin on the eplication of
Western Equine Encephalitis virus. Arch. Virol. 52(4): 341-5.
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de Julian-Ortiz JV, Galvez J, et al. 1999. Virtual combinatorial syntheses and computational screening of new potential anti-herpes compounds. J Med Chem. 42(17): 3308-14.
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Ahn YJ, Park SJ, et al. 2000. Cordycepin: Selective growth inhibitor derived from liquid culture of
Cordyceps militaris against Clostridium spp. J Agric Food Chem. 48(7): 2744-8.
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Zhou X, Meyer CU, et al. 2002. Effects of Cordycepin on interleukin-10 production of human peripheral blood mononuclear cells. Eur J Pharmacol. 453(2-3): 309-17.
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Koc Y, Urbano AG, et al. 1996. Induction of apoptosis by
Cordycepin in ADA-inhibited Tdt-positive leukemia cells. Leukemia. 10(6): 1019-24.
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Sugar A, McCaffrey R. 1998. Antifungal activity of 3’-deoxyadenosine (cordycepin). Antimicrob Agents Chemother. 42(6): 1424-27.
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Kodama EN, McCaffery RP, et al. 2000. Antileukemic activity and mechanism of action of
Cordycepin against terminal deoxynucleotidyl transferase-positive (TdT+) leukemic cells. 59(3): 273-81.
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Hahy BW, Cox NJ, et al. 1973. Multiplication of influenza virus in the presence of
Cordycepin, an inhibitor of cellular RNA synthesis. 243(127): 172-4.
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Robertson JB, Williams JR, Little JB. 1978. Enhancement of radiation killing of cultured mammalian cells by
Cordycepin. Int J Radiat Biol Relat Stud Phys Chem Med. 34(5): 417-29.
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Hiraoka W, Tanabe K, et al. Metabolic effects of 3’-deoxyadenosine (cordycepin) and 2-halo 3’-deoxyadenosine on repair of
X-ray induced potentially lethal damage in Chinese hamster V79 cells. Radiat Res. 114(2): 231-9.
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Becker Y, Olshevsky U. 1973. Inhibition of
Herpes simplex virus replication by Cordycepin. Isr J Med Sci. 9(11): 1581-5.
-
Hiraoka W, Kuwabara M, Sato F. 1990. Effects of 3’-deoxyadenosine (cordycepin) on the repair of
X-ray induced DNA single- and double-strand breaks in Chinese hamster V79 cells. J Radiat Res (Tokyo). 31(2): 156-61.
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Yokoiyama A, Kada T, Kuroda Y. 1992. An inhibitor of potentially lethal damage (PLD) repair reduces the frequency of gamma-ray-induced mutation in cultured Chinese hamster V79 cells. Mutat Res. 268(2): 247-54.
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